Inside, the Serena could transport up to eight occupants, depending on the seating configuration. There were three rows of seats, with plenty of room for all of them. In the back, the bench was retractable on the side panels while the second row could have been folded, transforming the car into a large furniture carrier.
The first-ever Nissan hybrid MPV offered a choice of two power outputs. The gasoline unit was a 2.0-liter four-pot engine and paired to an electric motor and a CVT transmission.